Leptosiphon pachyphyllus is found only in the Sierra Nevada, Owens Valley, the White Mountains and the Inyo Mountains in California, extending a little way into Nevada. Plants are short, just a few inches tall, bearing lobed leaves at close, evenly-spaced intervals along the stem; there are no basal leaves. Leaves are divided almost to the base; lobes are linear to narrowly lanceolate, pointed at the tip, and at most 0.6 inches long. Stems and leaves have a covering of short, non-glandular hairs.
The inflorescence is an open cluster of a small number of flowers, subtended by leaf-like bracts. Calyces, around a third of an inch long, are divided almost to the base into five narrow, tapering, equal-sized lobes, while the slightly longer corollas have a yellow tube, narrowly funnel-shaped, and five white lobes, spreading to slightly reflexed. The five stamens are exserted, and all are attached at the same level.
The similar
leptosiphon nuttallii has leaf lobes that are narrower and more linear in shape, and also corolla tubes equal in length to the calyx lobes rather than longer.