Opuntia santa-rita is an attractive species with limited distribution in far south Arizona, mostly around Nogales - between the Baboquivari and Santa Rita mountains. The mostly or completely spineless pads are bluish green in color with a distinct purple tinge, more evident during dry or cold weather, and they have a neat, regular array of areoles bearing yellow or brown glochids.
Pads are circular or slightly ovate in shape, about 7 inches across. If present, spines are white or pale yellow, up to 1.5 inches long, one per areole, and found mostly along pad edges. The species hybridizes with
opuntia chlorotica, forming a purplish-padded plant with more spines, similar to
opuntia gosseliniana.