Click on a city for full hotel listings and location maps, or a hotel for reservations. The hotels featured are either right beside the interstate exit or at most half a mile from it. I-40 crosses the flat plains of the Texas Panhandle from New Mexico to Oklahoma, passing only one major city (Amarillo).

All Texas interstates: I-2, I-10, I-20, I-27, I-30, I-35, I-35E, I-35W, I-37, I-40, I-44, I-45.

Please refer to the disclosure notice for information about the affiliate (commissionable) links on this page.

Exit	Roads	City	Hotels
	Interstate 40 in New Mexico
0	I-40 Bus, Route 66	Glenrio
15	Ivy Rd
18	FM 2858, Gruhlkey Road
22	TX 214, I-40 Bus	Adrian
23	TX 214	Adrian
28	FM 3319	Landergin
35	I-40 Bus east, FM 3319	Vega
36	US 385	Vega	★★★★★ Days Inn by Wyndham Vega
37	I-40 Bus west
42	Everett Road
49	FM 809	Wildorado
54	Adkisson Road
57	RM 2381	Bushland
60	Arnot Road
62A	Hope Road, Helium Road
62B	I-40 Bus east (Amarillo Boulevard)
64	Loop 335 (Soncy Road), Helium Road	Amarillo	★★★★★ Holiday Inn Amarillo West Medical Center ★★★★★ Hampton Inn & Suites Amarillo West ★★★★★ Country Inn & Suites by Radisson, Amarillo I-40 West ★★★★★ Homewood Suites by Hilton Amarillo ★★★★★ Hilton Garden Inn Amarillo ★★★★★ Springhill Suites Amarillo ★★★★★ Holiday Inn Express & Suites Amarillo West ★★★★★ Microtel Inn & Suites by Wyndham Amarillo West
65	Coulter Street	Amarillo	★★★★★ Courtyard Amarillo ★★★★★ TownePlace Suites Amarillo West/Medical Center ★★★★★ Best Western Plus Medical Center Hotel ★★★★★ Fairfield Inn Amarillo ★★★★★ Sleep Inn & Suites Amarillo ★★★★★ Spark by Hilton Amarillo West ★★★★★ Days Inn by Wyndham Amarillo - Medical Center
66	Bell Street, Avondale Street, Wolflin Avenue	Amarillo
67	Western Street, Avondale Street	Amarillo	★★★★★ Staybridge Suites Amarillo-Western Crossing ★★★★★ Candlewood Suites Amarillo-Western Crossing ★★★★★ Comfort Suites Amarillo
68A	Julian Boulevard, Paramount Boulevard	Amarillo	★★★★★ Comfort Inn & Suites Amarillo East ★★★★★ Super 8 by Wyndham Amarillo West
68B	Georgia Street, Crockett Street	Amarillo	★★★★★ Holiday Inn Express Hotel & Suites Amarillo
69A	Crockett Street	Amarillo
69B	Washington Street - Amarillo College	Amarillo
70	Interstate 27 south - exit 123B, US 60, US 87, US 287	Amarillo
71	Ross-Osage Street, Arthur Street	Amarillo	★★★★★ Four Points by Sheraton Amarillo Downtown ★★★★★ Comfort Inn & Suites Amarillo ★★★★★ Best Western Plus Amarillo East Hotel ★★★★★ Fairfield Inn & Suites Amarillo Downtown ★★★★★ Quality Inn Amarillo East ★★★★★ Sleep Inn Amarillo Airport ★★★★★ Microtel Inn & Suites by Wyndham Amarillo ★★★★★ Baymont by Wyndham Amarillo East ★★★★★ Days Inn by Wyndham Amarillo East
72A	Loop 362, Nelson Street, Quarter Horse Drive	Amarillo	★★★★★ Super 8 by Wyndham Amarillo Central
72B	Loop 395, Grand Street, Bolton Street	Amarillo	★★★★★ Best Western Santa Fe
73	Eastern Street, Bolton Street	Amarillo
74	Whitaker Road	Amarillo	★★★★★ Holiday Inn Amarillo East ★★★★★ Hampton Inn & Suites Amarillo East ★★★★★ Home2 Suites by Hilton Amarillo East
75	Loop 335 (Lakeside Drive)	Amarillo	★★★★★ Super 8 by Wyndham Amarillo East
76	Spur 468, Airport Boulevard	Amarillo	★★★★★ Holiday Inn Express Hotel & Suites Amarillo East ★★★★★ Fairfield Inn & Suites Amarillo Airport
77	FM 1258 (Pullman Road)	Amarillo
78	US 287 south	Amarillo
80	Spur 228, Jackrabbit Road
81	FM 1912
85	Durrett Road
85	I-40 Bus west (Amarillo Boulevard), FM 2575
87	FM 2373
89	FM 2161
96	TX 207	Conway
98	TX 207
105	FM 2880
109	FM 294
110	I-40 Bus east	Groom
112	FM 295	Groom
113	FM 2300	Groom
114	I-40 Bus west	Groom
121	TX 70 north
124	TX 70 south
128	FM 2477
132	Johnson Ranch Road
135	Loop 271, FM 291	Alanreed
141	I-40 Bus	McLean
142	TX 273, FM 3143	McLean
143	I-40 Bus	McLean
146	County Line Road
148	FM 1443 (Kellerville Road)
152	FM 453 (Pakan Road)
157	FM 1547, FM 2474, FM 3075	Lela
161	I-40 Bus east	Shamrock
163	US 83, Main Street	Shamrock	★★★★★ Holiday Inn Express Hotel & Suites-Shamrock North ★★★★★ Best Western Plus Shamrock Inn & Suites ★★★★★ Sleep Inn & Suites Shamrock
164	I-40 Bus west	Shamrock
167	FM 2168 (Daberry Road)
169	FM 1802 (Carbon Black Road)
176	Spur 30 east
	(mile 178 - Oklahoma state line)