Click on a city for full hotel listings and location maps, or a hotel for reservations. The hotels featured are either right beside the interstate exit or at most half a mile from it. From the border with Colorado, I-25 in Wyoming heads north, terminating at the intersection with I-90 in Buffalo.

All Wyoming interstates: I-25, I-80, I-90.

Please refer to the disclosure notice for information about the affiliate (commissionable) links on this page.

Exit	Roads	City	Hotels
	Interstate 25 in Colorado
	(mile 0 - Colorado state line)
2	Terry Ranch Road (WY 223)
7	I-25 Bus (College Drive, US 87, WY 212)	Cheyenne	★★★★★ Quality Inn Cheyenne
8	Interstate 80 - exit 359
9	US 30 (West Lincolnway)	Cheyenne	★★★★★ Holiday Inn Express Hotel & Suites Cheyenne ★★★★★ Candlewood Suites Cheyenne ★★★★★ Fairfield Inn & Suites Cheyenne Southwest/Downtown Area ★★★★★ SureStay Plus Hotel by Best Western Cheyenne ★★★★★ Comfort Inn & Suites Cheyenne ★★★★★ Microtel Inn & Suites by Wyndham Cheyenne ★★★★★ Days Inn by Wyndham Cheyenne
10D	WY 210 (Happy Jack Road), Missile Drive	Cheyenne
10B	Warren AFB Gate 2	Cheyenne
11	Pershing Boulevard, Randall Avenue - Warren AFB Gate 1	Cheyenne
12	I-25 Bus, US 85 (Central Avenue, WY 224)	Cheyenne	★★★★★ Comfort Suites Cheyenne
13	Vandehei Avenue	Cheyenne
16	WY 211 (Horse Creek Road)
17	US 85 (Torrington Road)
21	Ridley Road, Little Bear Road
25	Atlas Road, Co Road 224
29	Whitaker Road
34	Nimmo Road
39	Little Bear Community
47	Bear Creek Road
54	I-25 Bus (WY 211, WY 313)	Chugwater
57	I-25 Bus (Ty Road, WY 321)
65	Slater Road (WY 314)
66	Hunton Road
68	Antelope Road
70	Bordeaux Road
73	WY 34
78	I-25 Bus, US 87	Wheatland	★★★★★ Days Inn by Wyndham Wheatland
80	I-25 Bus, US 87	Wheatland	★★★★★ Best Western Torchlite Motor Inn ★★★★★ Super 8 by Wyndham Wheatland
84	Laramie River Road
87	Johnson Road
92	US 26
94	El Rancho Road, Pepper Road
100	Cassa Road (WY 319)
104	Middle Bear
111	Glendo Highway (WY 319)	Glendo
126	US 18/20	Orin
135	I-25 Bus	Douglas
140	I-25 Bus, US 20/26, Yellowstone Highway	Douglas	★★★★★ Hampton Inn & Suites Douglas ★★★★★ Holiday Inn Express Hotel & Suites Douglas ★★★★★ Sleep Inn & Suites Douglas ★★★★★ Super 8 by Wyndham Douglas
146	La Prele Road (WY 96)
150	Inez Road
151	Natural Bridge
154	Barber Road
156	Bixby Road
160	I-25 Bus, US 20/26
165	I-25 Bus. south (WY 95)	Glenrock
182	Hat Six Road (WY 253)	Casper, Evansville	★★★★★ Holiday Inn Casper East - McMurry Park ★★★★★ Best Western Plus Casper Inn & Suites ★★★★★ MainStay Suites Casper ★★★★★ Sleep Inn & Suites Evansville
185	Wyoming Boulevard (WY 258), Curtis St	Casper, Evansville	★★★★★ Courtyard Casper ★★★★★ Residence Inn Casper ★★★★★ Holiday Inn Express Casper I-25 ★★★★★ Candlewood Suites Casper ★★★★★ Comfort Inn Evansville ★★★★★ Baymont by Wyndham Casper East ★★★★★ Rodeway Inn Casper ★★★★★ Super 8 by Wyndham Evansville
186	I-25 Bus, US 20/26/US 87 (Beverly Street, Bryan Stock Trail)	Casper
187	McKinley Street	Casper
188A	I-25 Bus, US 87 (Center Street, WY 255)	Casper	★★★★★ Hampton Inn & Suites Casper ★★★★★ Best Western Platte River Hotel and Event Center ★★★★★ Quality Inn & Suites Casper
188B	WY 220 (Poplar Street)	Casper
189	US 20/26 (Events Drive)	Casper	★★★★★ Hilton Garden Inn Casper
191	Wardwell Road (WY 254)
197	Ormsby Road
210	WY 259 (Horseshoe Road)
216	(ranch exit)
223	Shepperson Road
227	WY 387
235	Tisdale Mountain Road
246	Powder River Road
249	TTT Road (WY 196)
254	Mayoworth Road, Sussex Lane (WY 191)	Kaycee
265	Reno Road
280	Middle Fork Road
291	Trabing Road
298	I-25 Bus, US 87 (Main Street)	Buffalo
299	US 16 (I-90 Bus), Hart Street	Buffalo	★★★★★ Holiday Inn Express Hotel & Suites Buffalo ★★★★★ SureStay Plus Hotel by Best Western Buffalo ★★★★★ Quality Inn Buffalo ★★★★★ Super 8 by Wyndham Buffalo ★★★★★ Rodeway Inn Buffalo
300	Interstate 90 - exit 56B